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Importance of Zonulin and Histamine-Jim LaValle Clinical R.Ph.,CCN.,MT.,N.D.
Why Test Annually for Food Allergies, Sensitivities and Intolerances-Jim LaValle Clinical R.Ph.,CCN.,MT.,N.D.
Understanding Food Allergies and Intolerance-Jim LaValle Clinical R.Ph.,CCN.,MT.,N.D.
Food Allergens and Weight Issues: Could your Food Allergies be the Root Cause of your Weight Gain?
Complement plays a role in how inflammatory an IgG antibody is. Complement binds to IgG and creates a synergistic effect in terms of increasing inflammation. The combination of complement and IgG together can increase inflammation 1000 to 10,000-fold.
IgE and IgG should be measured together because they each independently play a role in symptoms to foods. You can either have an allergy/IgE response, or a sensitivity IgG response and both are independent of the other and create inflammation in the body.
Only testing IgG, is a bit like knowing total cholesterol, but not knowing how much HDL/good or LDL/bad cholesterol you have. The reason for this is that different IgG antibodies do different things depending on their subtype. IgG4 decreases IgE or allergic reactions. IgGI-III increase inflammation 3-72 hours after exposure. Also, different subtypes are increased in certain pathologies. For example, while IgG4 is generally good, there are a handful of pathologies where it is of concern, such as auto-immune hypothyroidism and eosinophilic esophagitis.
An allergy is mediated by IgE antibodies and creates an immediate reaction. A sensitivity is created by IgG antibodies and create a delayed response. While these general traits hold true, there are also times when IgG can amplify IgE reactions, and also some examples of if there is a very high level of IgG, it can have more of an immediate reaction too. They create independent reactions but can also influence each other. IgG is most typically a delayed reaction, but if high enough titers are present, it too can react within a few hours. The interplay between parts of the immune system demonstrates why it is best to look at multiple antibodies together.
IgG reactions are both the cause and the result of gut-based permeability. One way we develop IgG reactions is when the gut becomes more compromised or permeable. This allows for larger molecules than normal to “leak” through the gut. These larger molecules look antigenic to the immune system. T cells become sensitized and begin to make an immune response or produce antibodies. However, this is not the only way one can become sensitive to foods. Improper immune queuing in the GI tract, specifically in cells called the Peyer’s patches, can also cause this too.
Once an IgG reaction begins, it increases production of histamine and inflammation. This inflammation continues to damage the gut, thereby contributing to permeability. The best way to reduce gut-based inflammation, is to remove offending foods and work on healing the gut.
Food sensitivities can be related to weight gain in that they will create more inflammation in the body. Inflammation will cause an increase in the hormone leptin, which in turn tells adipose tissue to store more fat. Inflammatory foods create and irritation that leads to weight gain.
Yes! While the beginning of the reaction to foods start in the gut, it does not have to necessarily create gut pain, or be contained in the GI tract. The inflammatory process that starts in the gut can spread and even be more symptomatic in places outside of the gut. Many conditions such as headaches, pain and even depression have a gut-based cause but manifest in other areas of the body.
As quoted from Medscape:
“Specific IgE testing can be done through skin testing or blood testing. Testing should be based on the clinical scenario.”
In vitro tests assess antigen-specific IgE by testing the patient’s serum. Advantages to this method include the use of a single venipuncture that is not affected by medications. In vitro testing can be performed on patients with affected skin, such as dermatographism or atopic dermatitis. It is also a safer option if the patient is at risk for anaphylaxis. However, these tests are expensive compared with skin testing.
In this method, immunoassays measure interactions between antigens and antigen-specific antibodies. Immunoassays are often referred to as radioallergosorbent (RAST) testing, but that term is outdated because radiation is rarely used today. Current methods include enzyme-linked immunosorbent assay (ELISA), which uses antibodies linked to enzymes, as well as fluorescent enzyme immunoassays (FEIA) and chemiluminescent immunoassays, which use fluorescent generation with an enzyme.”
This method described on Medscape, the enzyme-linked immunosorbent assay or ELISA is the exact methodology performed by Infinite Labs. This is well established and routine.
As stated by Dr. Portnoy, MD in the publication Appropriate Allergy Testing and Interpretation:
“For the primary care provider, in vitro tests have the advantage that they are readily available, they require a single venipuncture, the office staff do not need to be trained to perform them, there is no risk to the patient since directed exposure to the allergen is avoided, and the tests are not affected if the patient has taken an antihistamine.”
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